Mercedes- Benz Brampton . Once your application is submitted, notification will be sent to your preferred Mercedes- Benz dealer, who you can then contact to arrange the last details. Get a car loan or lease for your new or pre-owned car from Mercedes-Benz of Lindon. You can also apply for credit in person at your preferred dealer. Q. Here you can do everything from calculating your overall budget to comparing monthly payments for the various Mercedes- Benz Financial Services programs. The Planning Centre will help you research not only what vehicles you can afford, but also move along the process at the dealer by allowing you to complete your credit application online. Q. If I apply for credit or access my account online, will the information I provide and view be secure? A. We safeguard your personal information with industry- standard security technology. In order to make sure you're receiving all the benefits of our safety and security procedures, we suggest you upgrade to the latest version of your Web browser. Q. Mercedes- Benz Financial Services also offers competitive financing programs customized specifically for pre- owned vehicles. Please inquire with your local dealer. Q. In a First Class Lease, how many kilometres can I drive? A. To fit the varied driving habits and preferences of our customers, Mercedes- Benz Financial Services offers several different lease programs. For Mercedes- Benz vehicles, our standard lease allows for 2. In addition, we offer an extra- kilometre lease if you drive more than 2. Q. How do I go about purchasing my vehicle at the end of my lease? A. You may have the option of extending your lease. Please contact a lease maturity advisor to review your options. Q. To inquire about your available options, please contact the Mercedes- Benz Financial Services servicing office via e- mail or by phone (see below). Mercedes- Benz Financial Services. Toll Free: 1- 8. 88- LEASE MB (1- 8. Just go to My Account and log in. After you? ve logged in, at the bottom of your account summary select Request Payoff Amount. Q. If you're looking to eliminate the hassles of stamps and snail mail, Pre- Authorized Payment is the ideal solution. Signing up for Pre- Authorized Payment is quick and easy. From My Account go to Update Profile > Payment Options and select Pre- Authorized Payment, supply the requested information on the Pre- Authorized Payment Authorization Agreement, then print, sign and mail it to us along with a void cheque. Please make sure all account holders have signed the Authorization Agreement before mailing. Mercedes- Benz Financial Services will notify you when your Pre- Authorized Payment account goes into effect, then we? Take advantage of lease specials and offers on a new Mercedes-Benz by exploring the new car specials currently available at Mercedes-Benz of Arcadia, serving Los Angeles. Mercedes-Benz Leases, Mercedes-Benz Used Leases, Used Mercedes-Benz Leases - Mercedes-Benz New Lease Programs - Mercedes-Benz New Lease Specials - LeaseTrader. Please remember that you must continue to send in your payments by mail until you are notified Pre- Authorized Payment has been established. If you prefer make a payment the conventional way, simply mail your payment to the Mercedes- Benz Financial Services office that services your account. Mercedes- Benz Financial Services. Matheson Blvd. East, Suite 5. Mississauga, Ontario. L4. W 0. A5. Toll Free: 1- 8. LEASE MB (1- 8. 88- 5. Q. There you have the opportunity to update your personal information or account preferences. Simply select the Personal Information tab, update your information as necessary and click Submit when finished. Your information will be updated for the account you accessed. Q. For assistance regarding your vehicle, visit the Mercedes- Benz website, or contact your local Mercedes- Benz dealer for the latest vehicle information. Pre- Authorized Payment is a free service available from Mercedes- Benz Financial Services that automatically deducts your monthly vehicle payment electronically from your chequing or savings account. Q. If the date happens to fall on a weekend or holiday, the debit is processed the next business day. Q. What do I need to qualify for Pre- Authorized Payment? A. All you need is a chequing account in good standing with a financial institution. To sign up, you'll also need to supply some basic personal information, chequing or savings account information, as well as your Mercedes- Benz Financial Services account number(s). Q. How do I sign up for Pre- Authorized Payment? A. Simply click on the Payment Options tab and complete the on- line form fields. You must also read & acknowledge the Pre- authorized Payment agreement and then submit your request for final processing. Q. You should receive an instant on- line as well as an e- mail confirmation stating that your Pre- Authorized Payment enrollment request has been received. It is very important that you continue mailing your payments if you don't receive either the on- line or the e- mail confirmation. Contact information is available on the Contact Us tab. Q. Pre- Authorized Payment can be used to make payments on as many Mercedes- Benz Financial Services accounts as you like. Simply complete the on- line Pre- Authorization enrolment for each account. Q. What if I change financial institutions? A. Transferring Pre- Authorized Payment to a new chequing account is easy. In order to modify your banking information on file just complete the on- line form fields, read & acknowledge the Pre- authorized Payment agreement and then submit your request for final processing. Mercedes-Benz Brampton. Sales: 1-888-436-3849 . Mercedes-Benz Financial Services offers several different lease programs. For Mercedes-Benz vehicles. Mercedes-Benz Leases - Mercedes-Benz Lease. Mercedes-Benz Leases Lease a 2016 Mercedes-Benz CLA250 $175.00 mo, 2016 Mercedes-Benz C300 $238.00 mo, 2014 Mercedes-Benz C250 $249.00 mo, 2016 Mercedes-Benz GLA250. It is an instant update and you should receive an on- line as well as an e- mail confirmation stating that your Pre- Authorized Payment banking information update has been received. Q. Simply contact Mercedes- Benz Financial Services via phone or e- mail. Contact information is available on the Contact Us tab. Q. Before calling, make sure to have your banking information and Mercedes- Benz Financial Services account number(s) available so that we can serve you as quickly and efficiently as possible. Mercedes- Benz Financial Services. Toll Free: 1- 8. 88- LEASE MB (1- 8.
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That's why we design our courses to be efficient, targeted and strategic so you make the most of every minute you spend prepping. Quality Content & Delivery. Our experts know how to design lessons based on how you're learning. That means we don't just record classroom lessons and put them in our Self- Paced prep—we design lessons FOR Self- Paced. Engaging Teachers. We love our teachers, and so will you. Download Crash Course for the GRE or any other file from Books. Files related to 'Crash Course'.We look for proven expertise and a sense of humor, and that's BEFORE we put them through 4. We guarantee progress in our programs that include live instruction and proctored exams. Princeton review crash course gre at grbookshop.com - Download free pdf files,ebooks and documents of princeton review crash course gre. Crash Course DVDs Biology: http:// The Video Game Crash of 1983: Crash Course Games #6 - Duration: 10 minutes. Crash Course for the GRE is designed for the student who has put off studying until the last minute, and it details the most critical tools and rules you need to. Crash Course for the New GRE (Princeton Review) GRE, Graduate Record Examinations (Kaplan). Federal Register. Applications for New Awards; Training Program for Federal TRIO Programs. Three federal programs, known collectively as TRIO, 1 were therefore part of the Economic Opportunity Act of 1964 and aimed to improve college outcomes for first-generation college students and those from low-income families. Yet, 50 years later, these High. Title I—Financial Assistance To Local Educational Agencies For The Education Of Children Of Low-Income Families Title II—School Library. Upward Bound programs are funded by the US Department of Education, Federal TRIO Programs. Keeping College Within Reach: Sharing Best Practices for Serving Low-Income and First-Generation Students (Written Testimony). Start Preamble. AGENCY: Office of Postsecondary Education, Department of Education. ACTION: Notice. Overview Information: Training Program for Federal TRIO Programs (Training Program). Notice inviting applications for new awards for fiscal year (FY) 2. Catalog of Federal Domestic Assistance (CFDA) Number: 8. A. Dates: Applications Available: April 2. Deadline for Transmittal of Applications: May 2. Deadline for Intergovernmental Review: July 2. Full Text of Announcement. I. Funding Opportunity Description. Purpose of Program: The Training Program provides grants to train the staff and leadership personnel employed in, participating in, or preparing for employment in, projects funded under the Federal TRIO Programs to improve the operation of these projects. Priorities: This notice contains five absolute priorities and two competitive preference priorities. In accordance with 3. CFR 7. 5. 1. 05(b)(2)(iv) and 3. CFR 7. 5. 1. 05(b)(2)(ii), the absolute priorities are from section 4. G(b) of the Higher Education Act of 1. HEA), and the regulations for this program (3. CFR 6. 42. 2. 4). Interim Final Regulations for the ACG and National SMART Grant Programs 2005-11-07 (Final) Federal Perkins loan, Work-study, and supplemental educational opportunity grant programs- Natural Disaster Student Aid Fairness Act. TRIO programs are educational outreach programs designed to benefit disadvantaged students. The annual income thresholds used for these programs in the 48 contiguous states and the District of Columbia follows: One family member, $16,245 Two family. O address some of the financial challenges facing low-income students, federal policymakers enacted a provision in the 2008 Higher Education Opportunity Act (HEOA) that makes financial literacy3 a required service of all TRIO programs (or, in the case of McNair. The competitive preference priorities are from the Department's notice of final supplemental priorities and definitions for discretionary grant programs, published in the Federal Register on December 1. FR 7. 84. 86), and corrected on May 1. FR 2. 76. 37). Note: Each year, the Training Program projects must offer training covering every topic listed within the applicable priority or priorities. And, each year, one or more Training Program projects must provide training for new project directors. Each applicant must identify in its application how it will meet this requirement as provided in 3. CFR 6. 42. 1. 1. Absolute Priorities: For FY 2. Under 3. 4 CFR 7. Each application must address one of these absolute priorities. An applicant must submit a separate application for each absolute priority it proposes to address. These priorities are: Absolute Priority 1. Training to improve: reporting student and project performance and the rigorous evaluation of project performance in order to design and operate a model project funded under the Federal TRIO Programs. Number of expected awards: 1. Maximum award amount: $2. Absolute Priority 2. Training on: budget management, and the statutory and regulatory requirements for operation of projects funded under the Federal TRIO Programs. Number of expected awards: 1. Maximum award amount: $2. Absolute Priority 3. Training on: assessment of student needs; retention and graduation strategies, including both secondary and postsecondary retention and graduation strategies; and the use of appropriate educational technology in the operation of projects funded under the Federal TRIO programs. Number of expected awards: 1. Maximum award amount: $3. Absolute Priority 4. Training on: assisting students in receiving adequate financial aid from programs assisted under title IV of the HEA and from other programs; college and university Start Printed Page 2. Number of expected awards: 1. Maximum award amount: $2. Absolute Priority 5. Training on: strategies for recruiting and serving hard to reach populations—including students who are limited English proficient, students from groups that are traditionally underrepresented in postsecondary education, students with disabilities, students who are homeless children and youths (as this term is defined in Section 7. Mc. Kinney- Vento Homeless Assistance Act (4. U. S. C. 1. 14. 34a), students who are in foster care or are aging out of the foster care system, or other disconnected students. Number of expected awards: 1. Maximum award amount: $3. Competitive Preference Priorities: For FY 2. Under 3. 4 CFR 7. Competitive Preference Priority 1 and up to an additional five points to an application that meets Competitive Preference Priority 2, depending on how well the application meets each of these priorities. An applicant submitting an application under Absolute Priorities 1, 2, 3, or 5 may apply using only Competitive Preference Priority 2. An applicant submitting an application under Absolute Priority 4 may apply using one or both of the Competitive Preference Priorities. Therefore, the maximum number of competitive preference points an application under Absolute Priorities 1, 2, 3, or 5 can receive under this competition is 5 while the maximum number of competitive preference points an application under Absolute Priority 4 can receive under this competition is 1. These priorities are: Competitive Preference Priority 1—Increasing Postsecondary Success (up to 5 additional points). Background: Meeting the President's goal of restoring the United States to first in the world in the percentage of citizens holding college degrees or other postsecondary credentials will require significantly increasing the number of high- need students who graduate from high school prepared to succeed in higher education and careers and who have access to college or rigorous postsecondary career or technical training leading to a degree or certificate. It will also require increasing the rates at which young people and adults enroll in, persist in, and complete college or other postsecondary training. This priority is designed to support efforts to reach the President's goal. We are using Competitive Preference Priority 1—Increasing Postsecondary Success because the Department believes that the TRIO programs can play an important role in improving the postsecondary outcomes of its participants by placing greater emphasis on providing innovative college selection counseling strategies to match students with more selective institutions. Research indicates that many high- achieving low- income students do not enroll in the most selective colleges for which they are qualified, but that, when they do enroll in such institutions, they tend to have greater success. For example, applicants could describe the extent to which their projects combine training on traditional approaches to college advising, such as assistance with test preparation, research and admissions applications, and financial aid applications, with training on strategies to match students to institutions that are appropriate for their qualifications. Competitive Preference Priority 1: Projects that are designed to increase the number and proportion of high- need students who persist in and complete college or other postsecondary education and training. Competitive Preference Priority 2—Improving Productivity (up to 5 additional points). Background: We are using Competitive Preference Priority 2—Improving Productivity because we believe that it is more important than ever to support TRIO projects that are designed to significantly increase efficiency in the use of resources while improving student outcomes. A key performance measure for the Training Program is its cost effectiveness, based on the number of TRIO project personnel receiving training each year. Furthermore, cost per participant is considered in all TRIO programs. Applicants proposing projects designed to offer increased opportunities for high- quality training for more individuals—that is, to decrease the training cost per participant while improving participant outcomes—will be more likely to perform well on this efficiency measure. The Department continues to emphasize productivity in all TRIO programs for 2. Accordingly, both new and current grantees will need assistance learning about, selecting, and implementing strategies that can help them be more productive while improving student outcomes. In light of this emphasis, we are interested in Training Program projects that propose to work with TRIO projects on strategies that improve productivity. Competitive Preference Priority 2: Projects that are designed to significantly increase efficiency in the use of time, staff, money, or other resources while improving student learning or other educational outcomes (i. Such projects may include innovative and sustainable uses of technology, modification of school schedules and teacher compensation systems, use of open educational resources (as defined in this notice), or other strategies. Note 1: The types of projects identified above are suggestions for ways to improve productivity. We recognize that some of these examples, such as modification of teacher compensation systems, may not be relevant within the context of a particular application. Therefore, applicants addressing this priority may explain how they will provide training opportunities to the same or an increased number of individuals at a lower cost per participant while improving the quality of their training support. Applicants might also want to consider how they will provide training to TRIO staff to serve the same or an increased number of program participants at a lower cost per participant while improving the quality of their services. Start Printed Page 2. Maximum number of applications: In accordance with 3. CFR 6. 42. 7, each application must clearly identify the specific absolute priority for which a grant is requested and must address each of the topics listed under that specific absolute priority. An application for a grant under a specific absolute priority must address only that absolute priority. A grantee who wants to apply under more than one absolute priority must submit separate applications for each absolute priority. If an applicant submits more than one application for the same absolute priority, we will accept only the application with the latest “date/time received” validation and we will reject all other applications the applicant submits for that priority. For example, an application for a grant under Absolute Priority 1 must address only training described under that priority. Definitions: This definition is from the notice of final supplemental priorities and definitions for discretionary grant programs, published in the Federal Register on December 1. Ultimate Program Uninstaller DownloadUninstall Ultimate Video Downloader - Howto Removal. Download Ultimate Video Downloader Removal Tool. Tested Malware & Virus Free by Mc. Afee. Corruption or damage of the program can also lead to uninstall troubles. Uninstall problem can be a pain in the butt and drive you crazy. Well, take it easy and relax, luckily you've now come to the right place, by applying the below provided solution (both automatic and manual), you will be able to completely uninstall the program from your computer. Method one - Uninstall Ultimate Video Downloader with professional uninstaller program (the recommended way)Step 1: Click the below link to download Special Uninstaller, install it on your PC. Download Ultimate Video Downloader uninstaller here, install and launch it. 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GTA: Vice City Stories; GTA: Liberty City Stories. Regulation of AMPA Receptor Trafficking and Synaptic Plasticity. Abstract. AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made towards the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins. Introduction. The mammalian central nervous system is comprised of the incredibly complex connectivity between billions of neurons that are highly specialized for the fast processing and transmission of cellular signals. Communication between neurons, each of which contains thousands of synapses, underlies all basic and higher- order information processing essential for normal brain function. AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and. Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies. This chapter presents an analysis and a summarized synthesis of our present knowledge of the biology of the thyroid gland, phylogeny,ontogeny,anatomy,structure,general metabolism,regulatory factors. The ability of neural circuits to strengthen or weaken their connectivity forms a molecular basis underlying the experience- dependent changes in adaptive behaviors. Synaptic plasticity can be regulated at the presynaptic side by altering the efficacy of neurotransmitter release, or on the postsynaptic side by changing the density, types and properties of neurotransmitter receptors. AMPA receptors (AMPARs) are the principal ionotropic glutamate receptors that mediate fast excitatory synaptic transmission in mammalian brain. AMPARs are tetrameric assemblies of highly homologous subunits encoded by four different genes, Glu. A1- 4. The trafficking of AMPARs into and out of synapses is highly dynamic and is regulated by subunit specific AMPAR- interacting proteins as well as by various post- translational modifications that occur on their cytoplasmic carboxyl terminal (C- terminal) domains. The regulated trafficking of AMPARs is a major mechanism underlying activity- induced changes in synaptic transmission. In general, increases in AMPAR function at synapses result in the long- term potentiation (LTP) of synaptic strength, whereas removal of synaptic AMPARs leads to long- term depression (LTD) . This review focuses on recent advances providing new insights into the molecular control of AMPAR trafficking by proteins that directly interact with the intracellular domains of Glu. A1 and Glu. A2. AMPAR Structure and Subunit Composition. All AMPAR subunits consist of highly homologous extracellular and transmembrane regions, but vary in their intracellular C- terminal domains. The Glu. A1, Glu. Glide: A New Approach for Rapid, Accurate Docking and Scoring. Enrichment Factors in Database Screening. Available protein structures: Pfam: structures: PDB: RCSB PDB; PDBe; PDBj: PDBsum: structure summary. Receptor tyrosine kinases (RTKs) are multidomain transmembrane proteins that function as sensors for extracellular ligands. Ligand receptor binding induces receptor dimerization and activation of their intracellular kinase. The identification of nitric oxide (NO 1), a small gaseous molecule, as a key biological signal was a landmark event in understanding regulation of many physiological functions. NO is composed of one nitrogen. Reactive oxygen species (ROS) and reactive nitrogen species (RNS, e.g. ROS and RNS are normally generated by tightly. Fig 2 The amino acid sequence homology among various metabotropic glutamate receptors. The phenogram in panel A illustrates the relationship between the three mGluR subgroups (Group I, II and III) and the individual receptors. Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named 'just another kinase' 1 and 2 (since they were just two. Conformational Plasticity Protein Kinases Pdf FilesConformational Plasticity Protein Kinases Pdf DownloadA4 and an alternatively spliced form of Glu. A2 (Glu. A2. L) contains long C- terminal domains, whereas the Glu. A2, Glu. A3 and an alternatively spliced form of Glu. A4 (Glu. A4. S) have shorter C- terminal domains (Figure 1). Expression of these subunits is developmentally regulated and is region specific. The C- termini of AMPAR subunits contains multiple regulatory elements that are subjected to various post- translational modifications, including protein phosphorylation, palmitoylation and ubiquitination. They also interact with scaffold proteins that bind signaling molecules as well as cytoskeletal proteins. Hence, the C- terminal domains of these subunits are crucial for the regulation of AMPAR function, including channel gating, trafficking and stabilization at synapses . AMPAR is a tetrameric channel assembled from two dimers of different subunits, such as Glu. A1/Glu. A2 and Glu. A2/Glu. A3. Each individual subunit is composed of a large extracellular ligand- binding domain.. AMPARs are assembled as two identical heterodimers with Glu. A1/2 being the most predominant AMPAR subtype in hippocampal pyramidal neurons, followed by Glu. A2/3 heteromers . The presence of Glu. A2 subunit has a profound impact on the biophysical property of AMPAR heteromeric complexes such that the Glu. A2- containing AMPARs are Ca. Glu. A2- lacking receptors are Ca. The subunit composition of AMPARs also governs the rules of AMPAR trafficking. The long- tailed AMPARs are important for the activity- dependent insertion of AMPARs to synapses during synaptic strengthening, such as LTP, whereas the short- tailed AMPARs appear to constitutively recycle in and out of synapses in the absence of activity, while internalization of both forms of AMPARs occurs during activity- dependent synaptic weakening, such as LTD . Enhanced receptor exocytosis and recycling occur during synaptic potentiation, while increased rate of endocytosis results in LTD . The delivery of AMPARs to the synapse requires dynein- or kinesin- dependent transport of AMPARs- containing vesicles (or endosomes) and SNARE- mediated fusion events at the plasma membrane. Recent studies have identified myosin. Va and Vb as the Ca. AMPARs . AMPARs are inserted into the plasma membrane in the soma or dendrites at extrasynaptic sites and travel to dendritic spines via lateral diffusion . However, the exact site of AMPAR exocytosis during LTP remains an ongoing debate. Several studies have reported that AMPARs first appear exclusively in the dendrites and are subsequently incorporated into synapses . Depending on the type of stimulation, internalized AMPARs undergo complex endosomal sorting processes that direct receptors either to recycle back to the plasma membrane or to be degraded by the lysosomal pathway . Local endocytosis and recycling at EZ may provide a pool of mobile AMPARs to maintain synaptic strength during LTP . This differential regulation is mainly due to interactions of intracellular C- terminal domain of Glu. A subunits with various components of the PSD and their associated proteins that function during receptor internalization and exocytosis. Synaptic Associated Protein 9. Da (SAP9. 7)SAP9. PSD9. 5- like membrane- associated guanylate kinase (PSD- MAGUK) protein family, which include PSD9. PSD9. 5 and SAP1. Despite being the first protein shown to bind directly to Glu. A1 C- terminal domain, the exact function of SAP9. SAP9. 7 also interacts with PKA anchoring molecule AKAP7. However, SAP9. 7 has also been shown to act early in the secretory pathway to facilitate maturation of AMPARs . While some studies have shown that overexpression of SAP9. AMPAR function at synapses . Nonetheless, expression of SAP9. AMPAR transmission reduced by loss of PSD9. PSD9. 3 function, suggesting a functional redundancy among PSD- MAGUK members . SAP9. 7 is believed to play critical role in AMPAR trafficking and LTP since it interacts with the PDZ motif of Glu. A1 and is targeted into spines upon Ca. MKII phosphorylation . However, knock- in mice lacking Glu. A1 PDZ motif show normal Glu. A1 synaptic localization and hippocampal LTP . This result is further corroborated by a recent study showing that SAP9. LTP . Further study is required to determine the precise function of SAP9. AMPAR trafficking and synaptic plasticity. Protein 4. 1. NThe actin cytoskeleton immobilizes glutamate receptors at synapses and plays a crucial role in basal synaptic transmission and synaptic plasticity . Protein 4. 1. N contains a spectrin/actin- binding domain and binds directly to the membrane proximal region of Glu. A1 C- terminal domain and regulate surface expression of Glu. A1 . Glu. A1 and 4. N interaction is enhanced by PKC phosphorylation of Glu. A1 on Ser- 8. 16 and Ser- 8. Glu. A1 palmitoylation on Cys- 8. A recent study showed that acute knockdown of protein 4. N decreases the frequency of Glu. A1 plasma membrane insertion on extrasynaptic sites and impairs the maintenance phase of LTP . Although another study showed normal basal synaptic transmission and LTP in 4. N/4. 1. G double knockout mice . The interaction of GRIP1 and 2 with Glu. A2/3 regulates the membrane trafficking and synaptic targeting of AMPARs and is critical for several forms of synaptic plasticity. Interestingly, the binding of Glu. A2 to GRIP1 is disrupted upon Glu. A2 phosphorylation on Ser- 8. Tyr- 8. 76 . Since Glu. A2 Ser- 8. 80 phosphorylation is crucial for the expression of LTD in both hippocampal SC- CA1 and cerebellar parallel fiber- Purkinje cell synapses, it has been hypothesized that detachment of GRIP1 upon Ser- 8. AMPARs leading to LTD . Importantly, cerebellar LTD is completely absent in the GRIP1/2 double knockout mice . Early studies suggested that GRIP1 interaction with kinesin heavy chain . Some studies, however, suggested that GRIP1 might function to retain AMPARs intracellularly . Recently, several studies have reported a role for GRIP1 in regulating AMPAR endosomal recycling. GRIP1 binding to neuron- enriched endosomal protein 2. Da (NEEP2. 1) promotes recycling of internalized AMPARs back to the plasma membrane through the recycling pathway . Disruption of GRIP1 and NEEP2. AMPARs in early endosomes and lysosomes, reduces Glu. A2 surface expression, which in turns abolishes the maintenance of LTP . Live- cell imaging analyses also reveal a delayed rate of AMPAR recycling following NMDA- induced endocytosis when measured using a Glu. A2 mutant that can not interact with GRIP1 . More importantly, AMPAR recycling is also slower in GRIP1/2 double knockout neurons . The interaction between GRIP1 and Sec. AMPAR targeting and insertion to the plasma membrane, could explain the recycling rate deficit seen in GRIP1/2 knockout neurons . GRASP- 1 facilitates the segregation of Rab. SNARE syntaxin 1. Knockdown of GRASP- 1 reduces activity- dependent recycling of AMPARs and maintenance of late phase LTP in hippocampal slices . Whether or not GRIP1 is required for GRASP- 1- mediated endosomal coupling still remains an open question. In addition, a newly identified AAA- ATPase, Thorase, directly interacts with GRIP1 and promotes the disassembly of GRIP1- AMPAR complexes in an activity- dependent manner . 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